A positive Hoffman reflex is typically associated with involvement of which neural pathways?

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Multiple Choice

A positive Hoffman reflex is typically associated with involvement of which neural pathways?

A positive Hoffmann sign signals involvement of the corticospinal (upper motor neuron) pathways. Flicking the terminal phalanx of the middle finger causes a brisk, involuntary flexion of the thumb and index finger when the pyramidal tract is affected, reflecting hyperexcitability of the spinal alpha motor neurons due to loss of cortical inhibition. This is a hallmark of upper motor neuron dysfunction, not a peripheral nerve problem, cerebellar disturbance, or autonomic dysfunction. So the sign specifically points to corticospinal tract involvement.

A positive Hoffmann sign signals involvement of the corticospinal (upper motor neuron) pathways. Flicking the terminal phalanx of the middle finger causes a brisk, involuntary flexion of the thumb and index finger when the pyramidal tract is affected, reflecting hyperexcitability of the spinal alpha motor neurons due to loss of cortical inhibition. This is a hallmark of upper motor neuron dysfunction, not a peripheral nerve problem, cerebellar disturbance, or autonomic dysfunction. So the sign specifically points to corticospinal tract involvement.

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